반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:27])[CH2:9][CH2:10][C:11]2[CH:16]=[CH:15][C:14]([S:17]([N:20]3[CH2:25][CH2:24][CH:23]([OH:26])[CH2:22][CH2:21]3)(=[O:19])=[O:18])=[CH:13][CH:12]=2)=[C:4]([NH:28][C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)[CH:3]=1.[O:35]=[C:36]([CH3:40])[C:37](Cl)=[O:38]>C1(C)C=CC=CC=1>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:27])[CH2:9][CH2:10][C:11]2[CH:12]=[CH:13][C:14]([S:17]([N:20]3[CH2:21][CH2:22][CH:23]([OH:26])[CH2:24][CH2:25]3)(=[O:19])=[O:18])=[CH:15][CH:16]=2)=[C:4]([N:28]([C:29]2[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=2)[C:37](=[O:38])[C:36](=[O:35])[CH3:40])[CH:3]=1참가 물질
4
반응 조건
- 온도
- 120 °C
실험 절차
To 1-(4-chloro-2-phenylamino-phenyl)-3-[4-(4-hydroxypiperidine-1-sulfonyl)-phenyl]propan-1-one (0.200 g) in toluene (20 mL) was added 2-oxopropanoyl chloride (0.427 g). The reaction mixture was heated at 120° C. for 3 h, then stirred at RT overnight to produce N-(5-chloro-2-{3-[4-(4-hydroxypiperidine-1-sulfonyl)-phenyl]-propionyl}-phenyl)-2-oxo-N-phenyl-propionamide, which was used without further purification.
출처 및 근거
- ORD 기록
- ord-4520d95aabbe4930829f415e6cea72d9
- 출처 데이터셋
- uspto-grants-2012_04
- 특허 번호
- US08163906B2
연결된 노트
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