HCID 59534044, 화합물 → {[(3,5-Dichloro-phenylsulphonyl)-naphthalen-2-yl-amino]-methyl}-phosphonic acid

HRID 1697278노트

반응식

HRID 1697278 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([S:9]([N:12]([CH2:23][P:24](=[O:41])([O:33]CC2C=CC=CC=2)[O:25]CC2C=CC=CC=2)[C:13]2[CH:22]=[CH:21][C:20]3[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=3)[CH:14]=2)(=[O:11])=[O:10])[CH:5]=[C:6]([Cl:8])[CH:7]=1>CO.[Pd]>[Cl:1][C:2]1[CH:3]=[C:4]([S:9]([N:12]([CH2:23][P:24](=[O:25])([OH:33])[OH:41])[C:13]2[CH:22]=[CH:21][C:20]3[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=3)[CH:14]=2)(=[O:11])=[O:10])[CH:5]=[C:6]([Cl:8])[CH:7]=1

참가 물질

4

반응물 1

HCID 59534044HCID 59534044, 화합물

생성물 1

HCID 25190980{[(3,5-Dichloro-phenylsulphonyl)-naphthalen-2-yl-amino]-methyl}-phosphonic acid

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

72 mg dibenzyl {[(3,5-dichloro-phenylsulphonyl)-naphthalen-2-yl-amino]-methyl}-phosphonate in 6 ml of methanol are hydrogenated in the presence of 3 mg palladium on activated charcoal (10% Pd). The catalyst is filtered through kieselguhr and the filtrate is evaporated down in vacuo. The flask residue is stirred with diisopropylether, suction filtered and dried.

후처리

  1. filtrationThe catalyst is filtered through kieselguhr
  2. customthe filtrate is evaporated down in vacuo
  3. filtrationfiltered
  4. customdried

출처 및 근거

ORD 기록
ord-e7f40591e54b4352a2d37238b414ed2a
출처 데이터셋
uspto-grants-2012_04
특허 번호
US08163911B2

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