1,2-Dichlorobenzene → 3-(3,5-Dichloro-2-oxo-1(2H)-pyrazinyl)-4-methyl-benzoic acid, methyl ester

참여 물질

역할	이름	HCID	투입량
반응물	1,2-Dichlorobenzene	HCID 7239	—
반응물	Oxalyl chloride	HCID 65578	—
반응물	Methyl 3-[(cyanomethyl)amino]-4-methylbenzoate	HCID 86663236	—
생성물	3-(3,5-Dichloro-2-oxo-1(2H)-pyrazinyl)-4-methyl-benzoic acid, methyl ester	HCID 86663235	—

반응 조건

온도	100 °C

반응 단계

To 3-[(cyanomethyl)amino]-4-methyl-benzoic acid, methyl ester (Example 1a, 1.2 g) was added 1,2-dichlorobenzene (20 mL) and oxalyl chloride (3 mL). The reaction was heated at 100° C. for four h before the volatiles were removed under reduced pressure. The residue was purified (SiO2 chromatography eluting with dichloromethane) to afford the subtitle compound (800 mg).

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US08163905B2
출처 데이터셋	uspto-grants-2012_04
ORD ID	ord-960619c4624647feb22b610c1cf95e28
출처 메모	uspto-grants-2012_04