Ammonia → 2-Hydroxy-alpha,alpha-dimethyl-benzeneacetamide

HRID 1697328

반응식

HRID 1697328 반응식
[CH3:1][C:2]1([CH3:12])[C:6]2[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=2[O:4][C:3]1=[O:11].[NH3:13]>CO>[OH:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[C:2]([CH3:12])([CH3:1])[C:3]([NH2:13])=[O:11]

참가 물질

4

반응물 2

HCID 222AmmoniaHCID 5956202(3H)-Benzofuranone, 3,3-dimethyl-

생성물 1

HCID 866632482-Hydroxy-alpha,alpha-dimethyl-benzeneacetamide

시약·촉매·용매 1

HCID 887Methanol용매

반응 조건

온도
25 °C

실험 절차

3,3-Dimethylbenzofuran-2(3H)-one (Example 198a, 19.7 g) was dissolved in 7N ammonia in methanol (50 mL) under nitrogen. The resulting solution was stirred at 25° C. for 16 h. The reaction mixture was evaporated to afford crude product. The solid was triturated with diethyl ether and filtered to give the subtitle compound (15.34 g).

후처리

  1. customThe reaction mixture was evaporated
  2. customto afford crude product
  3. customThe solid was triturated with diethyl ether
  4. filtrationfiltered

출처 및 근거

ORD 기록
ord-507d9bb5aaf2476ea2cb8e36ea591080
출처 데이터셋
uspto-grants-2012_04
특허 번호
US08163905B2

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