Hydrochloric Acid → 6-Trifluoromethoxy-2H-chromene-3-carboxylic acid

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To a microwave vial was added 6-trifluoromethoxy-2H-chromene-3-carbonitrile (100 mg, 0.4 mmol) and 10 M of sodium hydroxide in water (2 mL, 20 mmol). The reaction mixture was heated at 150° C. for 10 minutes in the microwave. The reaction mixture was acidified with conc. HCl then extracted with EtOAc (3×30 mL). The combined organics were washed with brine (3×30 mL), dried (MgSO4), filtered and concentrated, to give the product (42 mg) as a solid. m/z=258.9 (M−1), r.t.=3.43 mins. 1H NMR (400 MHz; CDCl3) δ 7.50 (1H, s), 7.11 (1H, dd), 7.04 (1H, d), 6.84 (111, d), 5.02 (2H, d).

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