Methanesulfonate → (2S,4R)-tert-butyl 2-(1-cyanocyclopropylcarbamoyl)-4-(2-(trifluoromethoxy)phenylthio)pyrrolidine-1-carboxylate

HRID 1697487노트

반응식

S([O-])(=O)(=O)C.[C:6]([O:10][C:11]([N:13]1[CH2:17][C@@H:16](OS(C)(=O)=O)[CH2:15][C@H:14]1[C:23](=[O:30])[NH:24][C:25]1([C:28]#[N:29])[CH2:27][CH2:26]1)=[O:12])([CH3:9])([CH3:8])[CH3:7].[F:31][C:32]([F:42])([F:41])[O:33][C:34]1[CH:39]=[CH:38][CH:37]=[CH:36][C:35]=1[SH:40]>>[C:6]([O:10][C:11]([N:13]1[CH2:17][C@H:16]([S:40][C:35]2[CH:36]=[CH:37][CH:38]=[CH:39][C:34]=2[O:33][C:32]([F:31])([F:42])[F:41])[CH2:15][C@H:14]1[C:23](=[O:30])[NH:24][C:25]1([C:28]#[N:29])[CH2:26][CH2:27]1)=[O:12])([CH3:9])([CH3:8])[CH3:7]

참가 물질

반응물 3

HCID 85257Methanesulfonate

HCID 27607322-(Trifluoromethoxy)thiophenol

HCID 59543742HCID 59543742, 화합물

생성물 1

HCID 67278971(2S,4R)-tert-butyl 2-(1-cyanocyclopropylcarbamoyl)-4-(2-(trifluoromethoxy)phenylthio)pyrrolidine-1-carboxylate

실험 절차

The reaction of the mesylate from experiment A2 with 2-trifluoromethoxy-benzenethiol yielded (2S,4R)-2-(1-cyano-cyclopropylcarbamoyl)-4-(2-trifluoromethoxy-phenylsulfanyl)-pyrrolidine-1-carboxylic acid t-butyl ester as a colorless foam. MS: 470.3 [M−H]−.

출처 및 근거

ORD 기록: ord-7947b64518a346b3850d6fabad114f6f
출처 데이터셋: uspto-grants-2012_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08163793B2

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