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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 1697561생성일: 2026년 10월 27일

2-Chloro-4-hydrazinylpyridine → (2S,4R)-4-(2-Chloro-benzenesulfonyl)-1-[2-(2-chloro-pyridin-4-yl)-5-methyl-2H-pyrazol-3-yl]-pyrrolidine-2-carboxylic Acid Methyl Ester

https://huagongshe.com/reaction/1697561

반응식

참여 물질

역할이름HCID투입량
반응물2-Chloro-4-hydrazinylpyridineHCID 21106442—
반응물(2S,4R)-methyl 4-(2-chlorophenylsulfonyl)-1-(3-oxobutanethioyl)pyrrolidine-2-carboxylateHCID 86646820—
생성물(2S,4R)-4-(2-Chloro-benzenesulfonyl)-1-[2-(2-chloro-pyridin-4-yl)-5-methyl-2H-pyrazol-3-yl]-pyrrolidine-2-carboxylic Acid Methyl EsterHCID 86646821—

반응 단계

In analogy to the procedure described in example 192 h, (2S,4R)-4-(2-chloro-benzenesulfonyl)-1-(3-oxo-thiobutyryl)-pyrrolidine-2-carboxylic acid methyl ester (example 253c) was reacted with (2-chloro-pyridin-4-yl)-hydrazine (CAS Reg. No. 700811-29-6) to give the title compound as colorless solid. MS (ESI): m/z=495.1 [M+H]+.

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US08163793B2
출처 데이터셋uspto-grants-2012_04
ORD IDord-050044ecae0b4b68926973c897924ca0
출처 메모uspto-grants-2012_04