Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methylhydrazine → (2S,4R)-1-(1,5-Dimethyl-1H-pyrazol-3-yl)-4-(2-trifluoromethyl-benzenesulfonyl)-pyrrolidine-2-carboxylic Acid Methyl Ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methylhydrazine | HCID 6061 | — |
| 반응물 | (2S,4R)-1-(3-oxo-thiobutyryl)-4-(2-trifluoromethyl-benzenesulfonyl)-pyrrolidine-2-carboxylic acid methyl ester | HCID 86646823 | — |
| 생성물 | (2S,4R)-1-(1,5-Dimethyl-1H-pyrazol-3-yl)-4-(2-trifluoromethyl-benzenesulfonyl)-pyrrolidine-2-carboxylic Acid Methyl Ester | HCID 66771910 | — |
반응 단계
In analogy to the procedure described in example 192 h, (2S,4R)-1-(3-oxo-thiobutyryl)-4-(2-trifluoromethyl-benzenesulfonyl)-pyrrolidine-2-carboxylic acid methyl ester (example 192 g) was reacted with methyl-hydrazine (CAS Reg. No. 60-34-4) to give the title compound as yellow solid. MS (ESI): m/z=432.1 [M+H]+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08163793B2 |
| 출처 데이터셋 | uspto-grants-2012_04 |
| ORD ID | ord-c26332c8a63b4b32b42574fd3860b232 |
| 출처 메모 | uspto-grants-2012_04 |