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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 1697576생성일: 2026년 10월 26일

Lithium Hydroxide → (2S,4R)-1-[2-(2-Chloro-pyridin-4-yl)-5-methyl-2H-pyrazol-3-yl]-4-(4-fluoro-2-trifluoromethyl-benzenesulfonyl)-pyrrolidine-2-carboxylic Acid

https://huagongshe.com/reaction/1697576

반응식

참여 물질

역할이름HCID투입량
반응물Lithium HydroxideHCID 3939—
반응물(2S,4R)-1-[2-(2-Chloro-pyridin-4-yl)-5-methyl-2H-pyrazol-3-yl]-4-(4-fluoro-2-trifluoromethyl-benzenesulfonyl)-pyrrolidine-2-carboxylic Acid Methyl EsterHCID 86646830—
생성물(2S,4R)-1-[2-(2-Chloro-pyridin-4-yl)-5-methyl-2H-pyrazol-3-yl]-4-(4-fluoro-2-trifluoromethyl-benzenesulfonyl)-pyrrolidine-2-carboxylic AcidHCID 86646831—

반응 단계

In analogy to the procedure described in example 253e, (2S,4R)-1-[2-(2-chloro-pyridin-4-yl)-5-methyl-2H-pyrazol-3-yl]-4-(4-fluoro-2-trifluoromethyl-benzenesulfonyl)-pyrrolidine-2-carboxylic acid methyl ester was saponified in the presence of lithium hydroxide to give the title compound as yellow solid. MS (ESI): m/z=533.1 [M+H]+.

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US08163793B2
출처 데이터셋uspto-grants-2012_04
ORD IDord-996e3f12314147a2b8cc4f9f94598b38
출처 메모uspto-grants-2012_04