2,2,2-Trifluoroethylhydrazine → (2S,4R)-1-[5-Methyl-2-(2,2,2-trifluoro-ethyl)-2H-pyrazol-3-yl]-4-(2-trifluoromethyl-benzenesulfonyl)-pyrrolidine-2-carboxylic Acid Methyl Ester

HRID 1697581

반응식

[CH3:1][O:2][C:3]([C@@H:5]1[CH2:9][C@@H:8]([S:10]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[C:19]([F:22])([F:21])[F:20])(=[O:12])=[O:11])[CH2:7][N:6]1[C:23](=S)[CH2:24][C:25](=O)[CH3:26])=[O:4].[F:29][C:30]([F:35])([F:34])[CH2:31][NH:32][NH2:33]>>[CH3:1][O:2][C:3]([C@@H:5]1[CH2:9][C@@H:8]([S:10]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[C:19]([F:20])([F:21])[F:22])(=[O:12])=[O:11])[CH2:7][N:6]1[C:23]1[N:32]([CH2:31][C:30]([F:35])([F:34])[F:29])[N:33]=[C:25]([CH3:26])[CH:24]=1)=[O:4]

참가 물질

반응물 2

HCID 787402,2,2-Trifluoroethylhydrazine

HCID 86646823(2S,4R)-1-(3-oxo-thiobutyryl)-4-(2-trifluoromethyl-benzenesulfonyl)-pyrrolidine-2-carboxylic acid methyl ester

생성물 1

HCID 86646834(2S,4R)-1-[5-Methyl-2-(2,2,2-trifluoro-ethyl)-2H-pyrazol-3-yl]-4-(2-trifluoromethyl-benzenesulfonyl)-pyrrolidine-2-carboxylic Acid Methyl Ester

실험 절차

In analogy to the procedure described in example 192 h, (2S,4R)-1-(3-oxo-thiobutyryl)-4-(2-trifluoromethyl-benzenesulfonyl)-pyrrolidine-2-carboxylic acid methyl ester (example 192 g) was reacted with 2,2,2-trifluoroethylhydrazine (CAS Reg. No. 5042-30-8) to give the title compound as yellow solid. MS (ESI): m/z=500.2 [M+H]+.

출처 및 근거

ORD 기록: ord-f12e2383da224093938f9aed3c9e95e1
출처 데이터셋: uspto-grants-2012_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08163793B2

연결된 노트

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