Lawesson's reagent → (2S,4R)-1-(2-Cyclobutyl-5-methyl-2H-pyrazol-3-yl)-4-(2-trifluoromethyl-benzenesulfonyl)-pyrrolidine-2-carboxylic Acid Methyl Ester

반응식

C(C1(NC([C@@H]2C[C@@H](S(C3C=CC=CC=3C(F)(F)F)(=O)=O)CN2C2N(C3C=CC=CC=3)N=C(C)C=2)=O)CC1)#N.COC([C@H]1C[C@@H](S(C2C=CC=CC=2C(F)(F)F)(=O)=O)CN1C(=O)CC(=O)C)=O.COC1C=CC(P2(SP(C3C=CC(OC)=CC=3)(=S)S2)=S)=CC=1.Cl.C1(NN)CCC1.[CH3:96][O:97][C:98]([C@H:100]1[CH2:104][C@@H:103]([S:105]([C:108]2[CH:113]=[CH:112][CH:111]=[CH:110][C:109]=2[C:114]([F:117])([F:116])[F:115])(=[O:107])=[O:106])[CH2:102][N:101]1[C:118]1[N:119]([CH:124]2[CH2:127][CH2:126][CH2:125]2)[N:120]=[C:121]([CH3:123])[CH:122]=1)=[O:99]>>[CH3:96][O:97][C:98]([C@@H:100]1[CH2:104][C@@H:103]([S:105]([C:108]2[CH:113]=[CH:112][CH:111]=[CH:110][C:109]=2[C:114]([F:117])([F:115])[F:116])(=[O:107])=[O:106])[CH2:102][N:101]1[C:118]1[N:119]([CH:124]2[CH2:127][CH2:126][CH2:125]2)[N:120]=[C:121]([CH3:123])[CH:122]=1)=[O:99]