Cyclobutylhydrazine--hydrogen chloride (1/1) → HCID 67278150, 화합물

HRID 1697628노트

반응식

HRID 1697628 반응식
[CH3:1][O:2][C:3]([C@@H:5]1[CH2:9][C@@H:8]([S:10]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[Cl:19])(=[O:12])=[O:11])[CH2:7][N:6]1[C:20](=S)[CH2:21][C:22](=O)[CH3:23])=[O:4].Cl.[CH:27]1([NH:31][NH2:32])[CH2:30][CH2:29][CH2:28]1>>[CH3:1][O:2][C:3]([C@@H:5]1[CH2:9][C@@H:8]([S:10]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[Cl:19])(=[O:11])=[O:12])[CH2:7][N:6]1[C:20]1[N:31]([CH:27]2[CH2:30][CH2:29][CH2:28]2)[N:32]=[C:22]([CH3:23])[CH:21]=1)=[O:4]

참가 물질

3

반응물 2

HCID 19432792Cyclobutylhydrazine--hydrogen chloride (1/1)HCID 86646820(2S,4R)-methyl 4-(2-chlorophenylsulfonyl)-1-(3-oxobutanethioyl)pyrrolidine-2-carboxylate

생성물 1

HCID 67278150HCID 67278150, 화합물

실험 절차

In analogy to the procedure described in example 192 h, (2S,4R)-4-(2-chloro-benzenesulfonyl)-1-(3-oxo-thiobutyryl)-pyrrolidine-2-carboxylic acid methyl ester (example 253c) was reacted with cyclobutylhydrazine hydrochloride (CAS Reg. No. 158001-21-9) to give the title compound as orange oil. MS (ESI): m/z=438.3 [M+H]+.

출처 및 근거

ORD 기록
ord-bbc23b763e584b7cbafef4bc920d5e7a
출처 데이터셋
uspto-grants-2012_04
특허 번호
US08163793B2

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