Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Lawesson's reagent → 4-{5-[(2S,4R)-2-Methoxycarbonyl-4-(2-trifluoromethyl-benzenesulfonyl)-pyrrolidin-1-yl]-3-methyl-pyrazol-1-yl}-piperidine-1-carboxylic Acid Benzyl Ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Lawesson's reagent | HCID 87949 | — |
| 반응물 | Benzyl 4-hydrazinylpiperidine-1-carboxylate | HCID 21098319 | — |
| 반응물 | (2S,4R)-1-(3-oxo-butyryl)-4-(2-trifluoromethyl-benzenesulfonyl)-pyrrolidine-2-carboxylic acid methyl ester | HCID 86646859 | — |
| 생성물 | 4-{5-[(2S,4R)-2-Methoxycarbonyl-4-(2-trifluoromethyl-benzenesulfonyl)-pyrrolidin-1-yl]-3-methyl-pyrazol-1-yl}-piperidine-1-carboxylic Acid Benzyl Ester | HCID 66770398 | — |
반응 단계
In analogy to the procedure described in example 308d, (2S,4R)-1-(3-oxo-butyryl)-4-(2-trifluoromethyl-benzenesulfonyl)-pyrrolidine-2-carboxylic acid methyl ester (example 192f) was reacted with Lawesson's reagent (CAS Reg. No. 19172-47-5) and 4-hydrazino-piperidine-1-carboxylic acid benzyl ester (CAS Reg. No. 280111-51-5) to give the title compound as yellow oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08163793B2 |
| 출처 데이터셋 | uspto-grants-2012_04 |
| ORD ID | ord-9b56101290c04bc299c08046e3f217fe |
| 출처 메모 | uspto-grants-2012_04 |