Trifluoroacetic acid → HCID 66771348, 화합물
반응식
C(OC([N:8]1[CH2:12][C@H:11]([S:13]([CH3:16])(=[O:15])=[O:14])[CH2:10][C@H:9]1[C:17](=[O:24])[NH:18][C:19]1([C:22]#[N:23])[CH2:21][CH2:20]1)=O)(C)(C)C.[F:25][C:26]([F:31])([F:30])[C:27]([OH:29])=[O:28]>ClCCl>[F:25][C:26]([F:31])([F:30])[C:27]([OH:29])=[O:28].[C:22]([C:19]1([NH:18][C:17]([C@@H:9]2[CH2:10][C@@H:11]([S:13]([CH3:16])(=[O:15])=[O:14])[CH2:12][NH:8]2)=[O:24])[CH2:20][CH2:21]1)#[N:23]참가 물질
4
반응 조건
- 온도
- 25 °C
실험 절차
To a solution of (2S,4R)-2-(1-cyano-cyclopropylcarbamoyl)-4-methanesulfonyl-pyrrolidine-1-carboxylic acid tert-butyl ester (500 mg, 1.39 mmol) in dichloromethane was added trifluoroacetic acid (0.5 ml, 6.99 mmol) at 0° C. The resulting mixture was stirred at 25° C. for 16 h. After complete consumption of starting material, the reaction mixture was evaporated in vacuo to get the crude title compound (500 mg, 1.39 mmol; quant.) which was used in next step without further purification. MS: m/z=258.0 [M+H]+.