4-Chloropyrimidine → HCID 59239486, 화합물

HRID 1697903노트

반응식

HRID 1697903 반응식
[CH2:1]([NH:3][C:4]([NH:6][C:7]1[CH:12]=[CH:11][C:10]([C:13]2[N:14]=[C:15]([N:23]3[CH2:28][CH2:27][O:26][CH2:25][C@@H:24]3[CH3:29])[C:16]3[CH2:22][CH2:21][NH:20][CH2:19][C:17]=3[N:18]=2)=[CH:9][CH:8]=1)=[O:5])[CH3:2].Cl[C:31]1[CH:36]=[CH:35][N:34]=[CH:33][N:32]=1>>[CH2:1]([NH:3][C:4]([NH:6][C:7]1[CH:8]=[CH:9][C:10]([C:13]2[N:14]=[C:15]([N:23]3[CH2:28][CH2:27][O:26][CH2:25][C@@H:24]3[CH3:29])[C:16]3[CH2:22][CH2:21][N:20]([C:31]4[CH:36]=[CH:35][N:34]=[CH:33][N:32]=4)[CH2:19][C:17]=3[N:18]=2)=[CH:11][CH:12]=1)=[O:5])[CH3:2]

참가 물질

3

반응물 2

HCID 6428344-ChloropyrimidineHCID 46913570Urea, N-ethyl-N'-[4-[5,6,7,8-tetrahydro-4-[(3S)-3-Methyl-4-Morpholinyl]pyrido[3,4-d]pyriMidin-2-yl]phenyl]-

생성물 1

HCID 59239486HCID 59239486, 화합물

실험 절차

Compound (dw) was prepared according to the procedure described in Example 2 by reacting (S)-1-ethyl-3-(4-(4-(3-methylmorpholino)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-2-yl)phenyl)urea with 4-chloropyrimidine. LC-MS: m/z=+475 (M+H)−.

후처리

  1. customCompound (dw) was prepared

출처 및 근거

ORD 기록
ord-7774ca615d934236bd77b5bb15a722b7
출처 데이터셋
uspto-grants-2012_04
특허 번호
US08163763B2

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