2-Chloro-5-fluoropyrimidine → HCID 59239113, 화합물
반응식
[CH2:1]([NH:3][C:4]([NH:6][C:7]1[CH:12]=[CH:11][C:10]([C:13]2[N:14]=[C:15]([N:23]3[CH2:28][CH2:27][CH:26]([O:29][CH3:30])[CH2:25][CH2:24]3)[C:16]3[CH2:22][CH2:21][NH:20][CH2:19][C:17]=3[N:18]=2)=[CH:9][CH:8]=1)=[O:5])[CH3:2].Cl[C:32]1[N:37]=[CH:36][C:35]([F:38])=[CH:34][N:33]=1>>[CH2:1]([NH:3][C:4]([NH:6][C:7]1[CH:8]=[CH:9][C:10]([C:13]2[N:14]=[C:15]([N:23]3[CH2:28][CH2:27][CH:26]([O:29][CH3:30])[CH2:25][CH2:24]3)[C:16]3[CH2:22][CH2:21][N:20]([C:32]4[N:37]=[CH:36][C:35]([F:38])=[CH:34][N:33]=4)[CH2:19][C:17]=3[N:18]=2)=[CH:11][CH:12]=1)=[O:5])[CH3:2]참가 물질
3
실험 절차
The compound was prepared following the general procedure in Example 287, substituting (S)-1-ethyl-3-(4-(4-(3-methylmorpholino)-6,7,8,9-tetrahydro-5H-pyrimido[5,4-d]azepin-2-yl)phenyl)urea for 1-ethyl-3-(4-(4-(4-methoxypiperidin-1-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-2-yl)phenyl)urea and substituting 4-Chloro-6-methylpyrimidine for 2-Chloro-5-fluoropyrimidine: LC-MS m/z=507 (M+H).
후처리
- customThe compound was prepared
출처 및 근거
- ORD 기록
- ord-4006e887fa3d4578a4cd5ca02cff2622
- 출처 데이터셋
- uspto-grants-2012_04