N-Methylethylamine → N-ethyl-5-(6-methoxy-1,3-benzothiazol-2-yl)-N-methylpyridin-2-amine

HRID 1698084노트

반응식

HRID 1698084 반응식
F[C:2]1[N:7]=[CH:6][C:5]([C:8]2[S:9][C:10]3[CH:16]=[C:15]([O:17][CH3:18])[CH:14]=[CH:13][C:11]=3[N:12]=2)=[CH:4][CH:3]=1.[CH2:19]([NH:21][CH3:22])[CH3:20]>O>[CH2:19]([N:21]([CH3:22])[C:2]1[CH:3]=[CH:4][C:5]([C:8]2[S:9][C:10]3[CH:16]=[C:15]([O:17][CH3:18])[CH:14]=[CH:13][C:11]=3[N:12]=2)=[CH:6][N:7]=1)[CH3:20]

참가 물질

4

반응물 2

HCID 12219N-MethylethylamineHCID 248037222-(6-Fluoropyridin-3-yl)-6-methoxy-1,3-benzothiazole

생성물 1

HCID 24803889N-ethyl-5-(6-methoxy-1,3-benzothiazol-2-yl)-N-methylpyridin-2-amine

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
100 °C

실험 절차

In a microwave vial were added 2-(6-fluoropyridin-3-yl)-6-methoxy-1,3-benzothiazole (75 mg, 0.289 mmol), water (2.0 ml-L) and ethylmethylamine (0.50 mL) and the reaction was heated in a microwave oven at 100° C. for 5 min. The precipitated product was filtered off, washed with water and dried in a desicator over P2O5 to yield the product (70 mg) as a beige solid. 1H NMR δ ppm 8.71 (d, 1H) 8.06 (dd, 2.53 Hz, 1H) 7.85 (d, 1H) 7.66 (d, 1H) 7.08 (dd, 1H) 6.76 (d, 1H) 3.84 (s, 3H) 3.64 (q, 2H) 3.08 (s, 3H) 1.12 (t, 3H); MS m/z (M+H) 300.

후처리

  1. filtrationThe precipitated product was filtered off
  2. washwashed with water
  3. dry with materialdried in a desicator over P2O5

출처 및 근거

ORD 기록
ord-400e8f56670140f68d4e9edc2bdc708f
출처 데이터셋
uspto-grants-2012_04
특허 번호
US08163928B2

반응 노트

불러오는 중…