Cyclopropylamine → N-(3-methoxy-5-(3-methoxypropoxy)benzyl)cyclopropanamine
반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:8]=[C:9]([O:11][CH2:12][CH2:13][CH2:14][O:15][CH3:16])[CH:10]=1)[CH:6]=O.[CH:17]1([NH2:20])[CH2:19][CH2:18]1>CC#N>[CH:17]1([NH:20][CH2:6][C:5]2[CH:8]=[C:9]([O:11][CH2:12][CH2:13][CH2:14][O:15][CH3:16])[CH:10]=[C:3]([O:2][CH3:1])[CH:4]=2)[CH2:19][CH2:18]1참가 물질
4
실험 절차
The title compound is synthesized by reductive amination of 3-Methoxy-5-(3-methoxy-propoxy)-benzaldehyde (2.50 g, 11.1 mmol) with cyclopropylamine (855 mg, 15.0 mmol) analogously to the preparation of Example 152. Yellow oil; MS: 266 [M+H]+; tR (HPLC, CombiScreen ODS-AM 50×4.6 mm; 5-100% CH3CN+0.1% TFA/H2O+0.1% TFA for 5 min then 100% CH3CN+0.1% TFA for 2 min, flow 2.0 ml/min): 2.48 min.
후처리
- custom2.48 min.
출처 및 근거
- ORD 기록
- ord-d762280aee18431fbee256841a2f242d
- 출처 데이터셋
- uspto-grants-2012_04
- 특허 번호
- US08163773B2
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