홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

4-Iodobenzoic acid → 4-[3-(4-Diethylamino-3-isopropylphenyl)-3-hydroxyprop-1-ynyl]benzoic acid

HRID 1698423
노트
인쇄 미리보기

반응식

HRID 1698423 반응식
I[C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][CH:3]=1.[CH2:11]([N:13]([CH2:27][CH3:28])[C:14]1[CH:19]=[CH:18][C:17]([CH:20]([OH:23])[C:21]#[CH:22])=[CH:16][C:15]=1[CH:24]([CH3:26])[CH3:25])[CH3:12]>[Cu](I)I.Cl[Pd](Cl)([P](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)[P](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1>[CH2:27]([N:13]([CH2:11][CH3:12])[C:14]1[CH:19]=[CH:18][C:17]([CH:20]([OH:23])[C:21]#[C:22][C:2]2[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][CH:3]=2)=[CH:16][C:15]=1[CH:24]([CH3:26])[CH3:25])[CH3:28]
참가 물질실험 절차출처 및 근거반응 노트

참가 물질

5

반응물 2

HCID 120854-Iodobenzoic acidHCID 866465761-(4-Diethylamino-3-isopropylphenyl)prop-2-yn-1-ol

생성물 1

HCID 672766054-[3-(4-Diethylamino-3-isopropylphenyl)-3-hydroxyprop-1-ynyl]benzoic acid수율 65.7%

시약·촉매·용매 2

HCID 83717Copper iodide촉매HCID 178418476HCID 178418476, 화합물촉매

실험 절차

In a manner analogous to example 1 f, the process is carried out by a reaction of 248 mg (1 mmol) of 4-iodobenzoic acid with 350 mg (1.4 mmol) of 1-(4-diethylamino-3-isopropylphenyl)prop-2-yn-1-ol in the presence of 11 mg (0.06 mmol) of copper iodide and 20 mg (0.03 mmol) of bis(triphenylphosphine)palladium chloride. 240 mg of 4-[3-(4-diethylamino-3-isopropylphenyl)-3-hydroxyprop-1-ynyl]benzoic acid are obtained in the form of a whitish solid (Mp=145° C., yield=46%).

출처 및 근거

ORD 기록
ord-cb25971327b1424a89abf89edc22f315
출처 데이터셋
uspto-grants-2012_04
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08163952B2

반응 노트

불러오는 중…

이 페이지에서참가 물질실험 절차출처 및 근거반응 노트