1,2-Dibromoethane → HCID 178477283, 화합물

HRID 1698494노트

반응식

HRID 1698494 반응식
Br[C:2]1[CH:7]=[CH:6][C:5]([S:8][CH2:9][CH3:10])=[CH:4][CH:3]=1.[Mg:11].[Br:12]CCBr>C1COCC1>[CH2:9]([S:8][C:5]1[CH:6]=[CH:7][C:2]([Mg:11][Br:12])=[CH:3][CH:4]=1)[CH3:10]

참가 물질

5

반응물 3

HCID 78391,2-DibromoethaneHCID 5462224MagnesiumHCID 70066501-Bromo-4-(ethylthio)benzene2회

생성물 1

HCID 178477283HCID 178477283, 화합물

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매3회

반응 조건

온도
50 °C

실험 절차

1-Bromo-4-(ethylthio)benzene (0.5 g, 2.3 mmol) was added to a stirred mixture of magnesium turnings (1.96 g, 82 mmol) in THF (10 mL). 1,2-Dibromoethane (30 μL) was then added and the mixture was heated at reflux to initiate the reaction. A solution of 1-bromo-4-(ethylthio)benzene (18.2 g, 84 mmol) in THF (60 mL) was added at such a rate to maintain the reaction mixture at gentle reflux. The reaction mixture was then stirred at 50° C. for 90 min and cooled to ambient temp to give a 1.16M solution of 4-(ethylthio)phenylmagnesium bromide in THF which was used in the next reaction.

후처리

  1. temperaturethe mixture was heated
  2. temperatureat reflux
  3. customthe reaction
  4. temperatureto maintain the reaction mixture at gentle reflux
  5. temperaturecooled to ambient temp

출처 및 근거

ORD 기록
ord-98cd55c83df54854bb20f0310eca59fd
출처 데이터셋
uspto-grants-2012_04
특허 번호
US08163956B2

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