1-Bromo-2-Chloroethane → 1-(2-Chloroethyl)-4-methylpiperidin-4-ol

반응식

[CH3:1][C:2]1([OH:8])[CH2:7][CH2:6][NH:5][CH2:4][CH2:3]1.Br[CH2:10][CH2:11][Cl:12]>>[Cl:12][CH2:11][CH2:10][N:5]1[CH2:6][CH2:7][C:2]([CH3:1])([OH:8])[CH2:3][CH2:4]1

참가 물질

반응물 2

HCID 78491-Bromo-2-Chloroethane

HCID 156491744-Methylpiperidin-4-ol

생성물 1

HCID 184498281-(2-Chloroethyl)-4-methylpiperidin-4-ol

실험 절차

4-methylpiperidin-4-ol (made via literature methods) and 1-bromo-2-chloroethane are reacted using the procedure for Example OO to afford 1-(2-chloroethyl)-4-methylpiperidin-4-ol.

출처 및 근거

ORD 기록: ord-b9232cd563084ef09b2a44b7cef652e3
출처 데이터셋: uspto-grants-2010_06
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07737283B2

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