Propionyl chloride → HCID 18176201, 화합물

HRID 1698945노트

반응식

HRID 1698945 반응식
[NH2:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([NH:12][C:13]3[CH:18]=[CH:17][CH:16]=[C:15]([Br:19])[CH:14]=3)=[N:7][CH:8]=[N:9]2)=[CH:4][CH:3]=1.[C:20](Cl)(=[O:23])[CH2:21][CH3:22]>C1COCC1>[Br:19][C:15]1[CH:14]=[C:13]([NH:12][C:6]2[C:5]3[C:10](=[CH:11][C:2]([NH:1][C:20](=[O:23])[CH2:21][CH3:22])=[CH:3][CH:4]=3)[N:9]=[CH:8][N:7]=2)[CH:18]=[CH:17][CH:16]=1

참가 물질

4

반응물 2

HCID 62324Propionyl chlorideHCID 53280457-Amino-4-[(3-bromophenyl)amino]quinazoline

생성물 1

HCID 18176201HCID 18176201, 화합물수율 38%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To a solution of 7-amino-4-[(3-bromophenyl)amino]quinazoline (163 mg, 0.52 mmol) in dry THF (3 mL) stirred under N2 at 25° C. was added dropwise propionyl chloride (0.05 mL, 0.58 (mmol). A yellow solid formed at once. After 1 hour the solid was collected by Buchner filtration and washed with ether then dried. Recrystallized from wet methanol afforded the desired product as bright yellow solid (81 mg, 38%),

후처리

  1. customA yellow solid formed at once
  2. filtrationAfter 1 hour the solid was collected by Buchner filtration
  3. washwashed with ether
  4. customthen dried
  5. customRecrystallized from wet methanol

출처 및 근거

ORD 기록
ord-be31159e65594bb1b6bc147f8e83804d
출처 데이터셋
uspto-grants-2002_02
특허 번호
US06344459B1

반응 노트

불러오는 중…