1-Bromo-2-Chloroethane → 1-(2-Chloroethyl)4-(trifluoromethyl)piperidin-4-ol

반응식

[F:1][C:2]([F:11])([F:10])[C:3]1([OH:9])[CH2:8][CH2:7][NH:6][CH2:5][CH2:4]1.Br[CH2:13][CH2:14][Cl:15]>>[Cl:15][CH2:14][CH2:13][N:6]1[CH2:5][CH2:4][C:3]([C:2]([F:1])([F:10])[F:11])([OH:9])[CH2:8][CH2:7]1

참가 물질

반응물 2

HCID 78491-Bromo-2-Chloroethane

HCID 179513214-(Trifluoromethyl)-4-piperidinol

생성물 1

HCID 184498291-(2-Chloroethyl)4-(trifluoromethyl)piperidin-4-ol

실험 절차

A solution of 4-(trifluoromethyl)piperidin-4-ol and 1-bromo-2-chloroethane are reacted using the procedure for Example OO to afford 1-(2-chloroethyl)-4-(trifluoromethyl)piperidin-4-ol.

출처 및 근거

ORD 기록: ord-be98669f9d524fc3869fd94f06b0badf
출처 데이터셋: uspto-grants-2010_06
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07737283B2

반응 노트

불러오는 중…