Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methylamine → N-methyl-3-nitrobenzamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methylamine | HCID 6329 | — |
| 반응물 | 3-Nitrobenzoic acid | HCID 8497 | — |
| 용매 | 1,2-Dichloroethane | HCID 11 | — |
| 생성물 | N-methyl-3-nitrobenzamide | HCID 221964 | — |
반응 단계
Commercially available 3-nitrobenzoic acid is reacted with methylamine and EDC under standard conditions to afford N-methyl-3-nitrobenzamide, which is reduced with LAH under standard conditions to afford N-methyl(3-nitrophenyl)methanamine, which is protected with benzylchloroformate under standard conditions to yield t-butyl 3-nitrobenzylmethylcarbamate. This material is nitrosated and reduced to yield t-butyl 3-hydrzazinobenzylmethylcarbamate.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07737283B2 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-4942823dcd4342c18d70523434e585ba |
| 출처 메모 | uspto-grants-2010_06 |