2,2-dimethylhexanedinitrile → HCID 11815890, 화합물

HRID 1699123노트

반응식

HRID 1699123 반응식
CC(C)([O-:4])C.[K+].[CH3:7][C:8]([CH3:16])([CH2:11][CH2:12][CH2:13][C:14]#[N:15])[C:9]#N>C1(C)C=CC=CC=1>[C:14]([CH:13]1[C:7](=[O:4])[C:8]([CH3:16])([CH3:9])[CH2:11][CH2:12]1)#[N:15]

참가 물질

4

반응물 2

HCID 2642192,2-dimethylhexanedinitrileHCID 23665647Potassium tert-butoxide

생성물 1

HCID 11815890HCID 11815890, 화합물수율 55%

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

A suspension of potassium t-butoxide (60.2 g, 0.54 mole) in toluene is treated with 2,2-dimethyladiponitrile (120.7 g, 0.87 mole) at 80° C., stirred for 2 hours, cooled to less than 30° C., and quenched with water. The phases are separated, the organic phase is stirred with 3N hydrochloric acid and filtered. The filtrate is concentrated in vacuo to give an oil which is distilled (2 torr, 150° C.) twice to afford the title product as a colorless oil, 65.7 g (98.5% pure, 55% yield), identified by gas chromatography.

후처리

  1. temperaturecooled to less than 30° C.
  2. customquenched with water
  3. customThe phases are separated
  4. stirringthe organic phase is stirred with 3N hydrochloric acid
  5. filtrationfiltered
  6. concentrationThe filtrate is concentrated in vacuo
  7. customto give an oil which
  8. distillationis distilled (2 torr, 150° C.) twice

출처 및 근거

ORD 기록
ord-4ef161acf469414ba17ef971bbc10a74
출처 데이터셋
uspto-grants-2002_02
특허 번호
US06344580B1

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