Benzene → Dihydroartemisinin ethyl ether

HRID 1699474

반응식

HRID 1699474 반응식
[CH3:1][C@H:2]1[C@@H:11]2[CH2:12][CH2:13][C:14]3([CH3:18])[O:16][O:17][C@:10]42[C@H:5]([C@@H:6]([CH3:20])[C@@H:7]([OH:19])[O:8][C@@H:9]4[O:15]3)[CH2:4][CH2:3]1.Cl[Si](C)(C)C.[CH:26]1C=CC=C[CH:27]=1>>[CH3:26][CH2:27][O:19][C@H:7]1[O:8][C@@H:9]2[O:15][C:14]3([CH3:18])[O:16][O:17][C@@:10]42[C@@H:5]([CH2:4][CH2:3][C@@H:2]([CH3:1])[C@@H:11]4[CH2:12][CH2:13]3)[C@H:6]1[CH3:20]

참가 물질

4

반응물 3

HCID 241BenzeneHCID 6397ChlorotrimethylsilaneHCID 456410Npc182939

생성물 1

HCID 72416Dihydroartemisinin ethyl ether

실험 절차

Another method is reported by Bhakuni et al. (Bhakuni R. S; Jain D. C and Sharma, R P., Indian J. Chemistry, 34B, 529-30 (1995). Arteether was prepared by dissolving dihydroartemisinin in alcohol and benzene mixture and then adding chlorotrimethylsilane as acid catalyst. The reaction was stirred for 2 hrs. at room temperature. The reaction mixture was washed with 10% sodium acetate solution and workup as usual method. The other products formed during the reaction were removed by column chromatography, to obtain pure arteether.

후처리

  1. customArteether was prepared
  2. customat room temperature
  3. washThe reaction mixture was washed with 10% sodium acetate solution and workup as usual method
  4. customThe other products formed during the reaction
  5. customwere removed by column chromatography

출처 및 근거

ORD 기록
ord-5cf77ee2a02043f39f01a2ebca8217db
출처 데이터셋
uspto-grants-2002_02
특허 번호
US06346631B1

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