참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | p-Toluenesulfonic acid | HCID 6101 | — |
| 반응물 | Ethyl orthoformate | HCID 31214 | — |
| 반응물 | Npc182939 | HCID 456410 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | Dihydroartemisinin ethyl ether | HCID 72416 | — |
반응 단계
Dihydroartemisinin (50 mg) was dissolved in dry ethanol (3 ml). Add 2 ml of triethylorthoformate and (25 mg) of p-toluenesulphonic acid. The reaction mixture was stirred at room temperature (20° C.) for 30 min. 50 ml of water was added in the reaction mixture The reaction product was extracted by dichloromethane (30 mil×3). The dichloromethane extract was dried over anhydrous sodium sulphate and evaporation of solvent under vacuum at 40° C. and yielded the arteether (52 mg).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US06346631B1 |
|---|
| 출처 데이터셋 | uspto-grants-2002_02 |
|---|
| ORD ID | ord-3ef54ade24794d0790ede2b239585204 |
|---|
| 출처 메모 | uspto-grants-2002_02 |
|---|
