Potassium Carbonate → 3-{3-[5-Cyano-1-(2,4-dimethoxybenzyl)-3-(3-indolyl)-2-oxo-2,3-dihydro-1H-imidazol-4-yl]-1-indolyl}-propyl methanesulfonate

참여 물질

역할	이름	HCID	투입량
반응물	Potassium Carbonate	HCID 11430	—
반응물	1,3-Propanediol, 1,3-dimethanesulfonate	HCID 27532	—
반응물	4-Cyano-3-(2,4-dimethoxybenzyl)-5-(3-indolyl)-1-(1-methyl-3-indolyl)-2,3-dihydroimidazol-2-one	HCID 18320729	—
용매	Dimethylformamide	HCID 6228	—
생성물	3-{3-[5-Cyano-1-(2,4-dimethoxybenzyl)-3-(3-indolyl)-2-oxo-2,3-dihydro-1H-imidazol-4-yl]-1-indolyl}-propyl methanesulfonate	HCID 18320759	—

반응 조건

온도	70 °C

반응 단계

To a solution 0.15 g (0.298 mmol) of the product from step b) in 2 ml of DMF was 0.40 g (1.72 mmol) of 1,3-propandiol bismethansulfonate and 0.50 g (3.62 mmol) of K2CO3. The mixture was stirred at 70° C. overnight and partitioned between EtOAc and water. The organic phase was washed with water and brine and finally evaporated. The residue was purified by chromatography on silica furnishing 0.11 g (59%) of the sub-title compound.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US06346625B1
출처 데이터셋	uspto-grants-2002_02
ORD ID	ord-8490e5a0de73423d845d5d859fab2c15
출처 메모	uspto-grants-2002_02