Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Chloro-3',4'-dihydroxyacetophenone → 2-(3,4-Dimethoxyphenyl)-4-(3,4-dihydroxyphenyl)thiazole hydrochloride
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Chloro-3',4'-dihydroxyacetophenone | HCID 66834 | — |
| 반응물 | 3,4-Dimethoxythiobenzamide | HCID 2758490 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 2-(3,4-Dimethoxyphenyl)-4-(3,4-dihydroxyphenyl)thiazole hydrochloride | HCID 18707355 | 22.2% |
반응 단계
In 20 ml of ethanol were suspended 367 mg of 3′,4′-dihydroxy-2-chloroacetophenone and 430 mg of 3,4-dimethoxythiobenzamide. The suspension was refluxed for 3 hours with heating. After cooling, the resulting crystals were collected by filtration, ethanol-washed and dried. The dried material was recrystallized from ethinol to obtain 160 mg of 2-(3,4-dimethoxyphenyl)-4-(3,4-dihydroxyphenyl) thiazole hydrochloride as yellow acicular crystals.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | USRE037556E1 |
| 출처 데이터셋 | uspto-grants-2002_02 |
| ORD ID | ord-c25dd21cfed945f88a32716b55257814 |
| 출처 메모 | uspto-grants-2002_02 |