4-Methylquinoline → HCID 18681464, 화합물

HRID 1699598노트

반응식

HRID 1699598 반응식
CC1C=CC(S([O-])(=O)=O)=CC=1.CN1C2C(S/C/1=[CH:22]\[C:23]1[C:32]3[C:27](=[CH:28][CH:29]=[CH:30][CH:31]=3)[N+:26]([CH3:33])=[CH:25][CH:24]=1)=CC=CC=2.[Br:34]C[CH2:36][CH2:37][CH2:38][C:39]([OH:41])=[O:40].N1C2C(=CC=CC=2)C(C)=CC=1>O1CCOCC1>[Br-:34].[C:39]([CH2:38][CH2:37][CH2:36][CH2:33][NH+:26]1[C:27]2[C:32](=[CH:31][CH:30]=[CH:29][CH:28]=2)[CH:23]([CH3:22])[CH:24]=[CH:25]1)([OH:41])=[O:40]

참가 물질

5

반응물 3

HCID 102854-MethylquinolineHCID 163685-Bromovaleric acidHCID 6438345Thiazole orange

생성물 1

HCID 18681464HCID 18681464, 화합물수율 70%

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

The synthesis of the carboxylic acid derivative of thiazole orange was adapted from published procedures, L. G. S. Brooker, et al., J. Am. Chem. Soc. 64:199-210 (1942); H. S. Rye, et al., Nucl. Acids Res. 20:2803-2812 (1992). 5.7 g (32 mmol) of 5-bromovaleric acid and 1.5 mL (11 mmol) of lepidine were refluxed in 30 mL of distilled dioxane under nitrogen overnight. The reaction mixture was allowed to cool to room temperature and filtered. The precipitate was washed twice with 10 mL of dioxane followed by 50 mL of petroleum ether to yield 2.6 g (70%) of pure 1-(4-Carboxybutyl)-4 -methyl-1,4-dihydro-quinolinium bromide.

후처리

  1. filtrationfiltered
  2. washThe precipitate was washed twice with 10 mL of dioxane

출처 및 근거

ORD 기록
ord-7efd199e35314598b888069d4ce7cbb9
출처 데이터셋
uspto-grants-2002_02
특허 번호
US06348317B1

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