Glycerol → Bupivacaine (USAN:INN:BAN)

HRID 1699646

반응식

HRID 1699646 반응식
[CH3:1][CH2:2][CH2:3][CH2:4][N:5]1[CH:10]([C:11]([NH:13][C:14]2[C:15]([CH3:21])=[CH:16][CH:17]=[CH:18][C:19]=2[CH3:20])=[O:12])[CH2:9][CH2:8][CH2:7][CH2:6]1.Cl.OCC(CO)O>O>[CH3:1][CH2:2][CH2:3][CH2:4][N:5]1[CH:10]([C:11]([NH:13][C:14]2[C:15]([CH3:21])=[CH:16][CH:17]=[CH:18][C:19]=2[CH3:20])=[O:12])[CH2:9][CH2:8][CH2:7][CH2:6]1

참가 물질

4

반응물 2

HCID 753GlycerolHCID 64737Bupivacaine Hydrochloride

생성물 1

HCID 2474Bupivacaine (USAN:INN:BAN)

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A composition suitable for administration in vaginal suppository form la prepared by weighing 2 mg of finely divided polynucleotide medicinal substance into a tared container, adding 10 ml of 0.5% bupivacaine HCl in purified water, to make a total of 10 g, and dissolving or mixing depending on the solubility of the medicinal substance; 70 g of glycerin is added and mixed; 20 g of granular gelatin is then added and the composition heated carefully on a steam bath until the gelatin is dissolved. The melted mixture is poured into chilled molds to yield 20 vaginal suppositories of 6 grams each containing 100 mcg of polynucleotide medicinal substance in admixture with 2.5 mg bupivacaine.

후처리

  1. customA composition suitable for administration in vaginal suppository form la prepared
  2. dissolutiondissolving
  3. additionmixing
  4. additionmixed
  5. addition20 g of granular gelatin is then added
  6. temperaturethe composition heated carefully on a steam bath until the gelatin
  7. dissolutionis dissolved
  8. additionThe melted mixture is poured
  9. temperatureinto chilled molds

출처 및 근거

ORD 기록
ord-6611d185663e46d5851fc4871102833d
출처 데이터셋
uspto-grants-2002_02
특허 번호
US06348449B1

연결된 노트

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