2-Methylpyrazolo[1,5-a]pyridine-5-carboxylic acid → HCID 22388192, 화합물

HRID 1699800노트

반응식

HRID 1699800 반응식
[CH3:1][C:2]1[CH:13]=[C:5]2[CH:6]=[C:7]([C:10]([OH:12])=[O:11])[CH:8]=[CH:9][N:4]2[N:3]=1.S(=O)(=O)(O)O.[CH2:19](O)[CH3:20]>>[CH3:1][C:2]1[CH:13]=[C:5]2[CH:6]=[C:7]([C:10]([O:12][CH2:19][CH3:20])=[O:11])[CH:8]=[CH:9][N:4]2[N:3]=1

참가 물질

3

반응물 2

HCID 223884352-Methylpyrazolo[1,5-a]pyridine-5-carboxylic acidHCID 73950302Sulphuric acid ethanol

생성물 1

HCID 22388192HCID 22388192, 화합물

실험 절차

2-Methylpyrazolo[1,5-a]pyridine-5-carboxylic acid (723 mg) was dissolved in 10% sulfuric acid/ethanol (20 ml) and the mixture was refluxed under heating for 2.5 hr. The reaction mixture was neutralized under ice-cooling, extracted with ethyl acetate and dried over magnesium sulfate. The residue was concentrated to dryness under reduced pressure. The residue was purified by silica gel column chromatography (hexane/ethyl acetate=4:1) to give the objective compound (707 mg) as a pale-brown powder.

후처리

  1. temperaturethe mixture was refluxed
  2. temperatureunder heating for 2.5 hr
  3. temperaturecooling
  4. extractionextracted with ethyl acetate
  5. dry with materialdried over magnesium sulfate
  6. concentrationThe residue was concentrated to dryness under reduced pressure
  7. customThe residue was purified by silica gel column chromatography (hexane/ethyl acetate=4:1)

출처 및 근거

ORD 기록
ord-0eb74a558249448293b4f2fb16b77954
출처 데이터셋
uspto-grants-2002_02
특허 번호
US06348474B1

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