Water → HCID 22388089, 화합물

HRID 1699916노트

반응식

HRID 1699916 반응식
N1C=CC=CC=1.S(Cl)([Cl:9])=O.[Cl:11][C:12]1[CH:19]=[C:18]([O:20][CH:21]([CH3:23])[CH3:22])[CH:17]=[CH:16][C:13]=1[CH2:14]O.O>ClCCl>[Cl:11][C:12]1[CH:19]=[C:18]([O:20][CH:21]([CH3:23])[CH3:22])[CH:17]=[CH:16][C:13]=1[CH2:14][Cl:9]

참가 물질

6

반응물 4

HCID 962WaterHCID 1049PyridineHCID 24386Thionyl ChlorideHCID 22388433[2-Chloro-4-(propan-2-yloxy)phenyl]methanol

생성물 1

HCID 22388089HCID 22388089, 화합물수율 106,483.797%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

Pyridine (0.5 ml) and thionyl chloride (0.18 mg) were successively added to a solution of 2-chloro-4-isopropoxybenzylalcohol (401 mg) in dichloromethane (2 ml) under ice-cooling, and the mixture was stirred for 1 hr. Water was added to the reaction mixture and the resulting product was extracted three times with hexane. The organic layers were combined, washed successively with 1N hydrochloric acid, a saturated aqueous solution of sodium hydrogencarbonate and saturated brine, and dried over anhydrous magnesium sulfate. The solvent was evaporated to give the objective compound (353 mg) as a yellow oil.

후처리

  1. temperaturecooling
  2. extractionthe resulting product was extracted three times with hexane
  3. washwashed successively with 1N hydrochloric acid
  4. dry with materiala saturated aqueous solution of sodium hydrogencarbonate and saturated brine, and dried over anhydrous magnesium sulfate
  5. customThe solvent was evaporated

출처 및 근거

ORD 기록
ord-09e3843cf1de40fcb8b861f0d708e3ed
출처 데이터셋
uspto-grants-2002_02
특허 번호
US06348474B1

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