4-Nitrophenol → 1-TERT-BUTOXY-4-NITROBENZENE

HRID 1700273노트

반응식

HRID 1700273 반응식
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([OH:10])=[CH:6][CH:5]=1)([O-:3])=[O:2].[C:11]1([CH3:17])[CH:16]=CC=C[CH:12]=1>C(OCC)(=O)C>[C:11]([O:10][C:7]1[CH:8]=[CH:9][C:4]([N+:1]([O-:3])=[O:2])=[CH:5][CH:6]=1)([CH3:17])([CH3:16])[CH3:12]

참가 물질

4

반응물 2

HCID 9804-NitrophenolHCID 1140Toluene

생성물 1

HCID 109433951-TERT-BUTOXY-4-NITROBENZENE

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

43.79 mmol of N-N-dimethylformamide di-tert-butyl acetal are added, at ambient temperature, to a solution of 10.78 mmol (1.5 g) of 4-nitrophenol in 10 ml of toluene. The reaction mixture is heated at reflux, with vigorous stirring, for 5 hours. The reaction mixture is diluted with ethyl acetate and then washed with water, with saturated aqueous sodium bicarbonate solution and then with 10% aqueous sodium chloride solution. The expected product is obtained by drying the organic phase and then concentrating.

후처리

  1. temperatureThe reaction mixture is heated
  2. temperatureat reflux, with vigorous stirring, for 5 hours
  3. washwashed with water, with saturated aqueous sodium bicarbonate solution

출처 및 근거

ORD 기록
ord-e9af818f89a4420d97f95a114b81ae7d
출처 데이터셋
uspto-grants-2002_02
특허 번호
US06350759B1

반응 노트

불러오는 중…