HCID 22181168, 화합물 → 4-[(1-Methylpiperidin-4-yl)oxy]-3-(trifluoromethyl)aniline
반응식
[CH3:1][N:2]1[CH2:7][CH2:6][CH:5]([O:8][C:9]2[CH:14]=[CH:13][C:12]([N+:15]([O-])=O)=[CH:11][C:10]=2[C:18]([F:21])([F:20])[F:19])[CH2:4][CH2:3]1.[H][H]>CO.[Pd]>[CH3:1][N:2]1[CH2:7][CH2:6][CH:5]([O:8][C:9]2[CH:14]=[CH:13][C:12]([NH2:15])=[CH:11][C:10]=2[C:18]([F:19])([F:20])[F:21])[CH2:4][CH2:3]1참가 물질
5
실험 절차
4-(N-methylpiperidin-4-yl)oxy-3-trifluoromethyl-1-nitrobenzene was dissolved in methanol in the presence of Pd/C. The solution was hydrogenated at 50 psi for 1 hour until hydrogen intake was completed. The catalyst was filtered off and the filtrate was concentrated to afford 4-(N-methylpiperidin-4-yl)oxy-3-trifluoromethylbenzenamine, >95%.
후처리
- filtrationThe catalyst was filtered off
- concentrationthe filtrate was concentrated
출처 및 근거
- ORD 기록
- ord-4cb246c39a594e9eb19deff567f829c9
- 출처 데이터셋
- uspto-grants-2002_02
- 특허 번호
- US06350761B1
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