Triethylamine → N-methyl-3-oxo-N-(3-phenyl-2-propene-1-yl)butyramide

HRID 1700338

반응식

HRID 1700338 반응식
[CH3:1][NH:2][CH2:3][CH:4]=[CH:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1.[CH2:12]=[C:13]1[O:17][C:15](=[O:16])[CH2:14]1.C(N(CC)CC)C.C(=O)([O-])O.[Na+]>C1(C)C=CC=CC=1>[CH3:1][N:2]([CH2:3][CH:4]=[CH:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)[C:15](=[O:16])[CH2:14][C:13](=[O:17])[CH3:12]

참가 물질

6

반응물 4

HCID 8471TriethylamineHCID 12661DiketeneHCID 189183N-methyl-3-phenylprop-2-en-1-amineHCID 516892Sodium Bicarbonate

생성물 1

HCID 53834343N-methyl-3-oxo-N-(3-phenyl-2-propene-1-yl)butyramide

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

0.736 g (5.0 mmol) of methyl-(3-phenyl-2-propene-1-yl)amine, 0.386 ml (5.0 mmol) of ketene dimer and 0.07 ml (0.50 mmol) of triethylamine were heated at 70° C. under stirring in 5 ml of toluene overnight. A saturated aqueous sodium hydrogencarbonate solution was added to the reaction mixture. After the extraction with ethyl acetate, the organic layer was dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure, and the residue was purified by the thin-layer silica gel chromatography (ethyl acetate) to obtain the title compound.

후처리

  1. extractionAfter the extraction with ethyl acetate
  2. dry with materialthe organic layer was dried over anhydrous sodium sulfate
  3. customThe solvent was evaporated under reduced pressure
  4. customthe residue was purified by the thin-layer silica gel chromatography (ethyl acetate)

출처 및 근거

ORD 기록
ord-017d1d1bc74d449d88a6fc94e654953c
출처 데이터셋
uspto-grants-2002_02
특허 번호
US06350762B1

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