1-(6-Chloro-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)cyclobutanecarboxaldehyde → HCID 18317883, 화합물

HRID 1700383노트

반응식

HRID 1700383 반응식
[Cl:1][C:2]1[CH:3]=[C:4]2[C:12](=[CH:13][CH:14]=1)[NH:11][C:10]1[CH:9]([C:15]3([CH:19]=[O:20])[CH2:18][CH2:17][CH2:16]3)[NH:8][CH2:7][CH2:6][C:5]2=1.[CH2:21]([Mg]Br)[CH3:22]>O1CCCC1>[Cl:1][C:2]1[CH:3]=[C:4]2[C:12](=[CH:13][CH:14]=1)[NH:11][C:10]1[CH:9]([C:15]3([CH:19]([OH:20])[CH2:21][CH3:22])[CH2:18][CH2:17][CH2:16]3)[NH:8][CH2:7][CH2:6][C:5]2=1

참가 물질

4

반응물 2

HCID 183179861-(6-Chloro-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)cyclobutanecarboxaldehydeHCID 178418443HCID 178418443, 화합물

생성물 1

HCID 18317883HCID 18317883, 화합물

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

실험 절차

2.32 g of the compound obtained in Step A of Example 115 in 150 ml of tetrahydrofuran are stirred for 4 hours at −30° C., under an inert atmosphere, in the presence of 15 ml of a 1M solution of ethylmagnesium bromide in tetrahydrofuran. After returning to ambient temperature, the mixture is worked up in conventional manner, then concentrated under reduced pressure, enabling the expected product to be isolated.

후처리

  1. customAfter returning to ambient temperature
  2. concentrationconcentrated under reduced pressure
  3. customto be isolated

출처 및 근거

ORD 기록
ord-f7e93ae2df364eb0a1ae40511447bdc3
출처 데이터셋
uspto-grants-2002_02
특허 번호
US06350757B1

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