참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | 6-(2-Fluorophenyl)-3-methyl-4,5,6,7-tetrahydrobenzofuran-4-one | HCID 18317758 | — |
| 반응물 | HCID 178418668 | HCID 178418668 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | HCID 178431137 | HCID 178431137 | 65.6% |
반응 단계
To a mixture of 6-(2-fluorophenyl)-3-methyl-4,5,6,7-tetrahydrobenzofuran-4-one (0.21 g) and aminoguanidine hydrochloride (95 mg) were added ethanol (17 ml) and 6N hydrochloric acid (0.074 ml), and the mixture was stirred at 90° C. for 2 hours and cooled. The reaction solution was concentrated under reduced pressure, and the residue was washed with ethanol, ethyl acetate and isopropylether, and dried to give (E)-6-(2-fluorophenyl)-4-guanidinoimino-3-methyl-4,5,6,7-tetrahydrobenzofuran hydrochloride (Compound 40) (0.19 g).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US06350749B1 |
|---|
| 출처 데이터셋 | uspto-grants-2002_02 |
|---|
| ORD ID | ord-965e977ba2df411fbe620732d0472ac3 |
|---|
| 출처 메모 | uspto-grants-2002_02 |
|---|
