참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Dichloromethane | HCID 6344 | — |
| 반응물 | Lorazepam ethanol | HCID 18318790 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | Lorazepam | HCID 3958 | 97.2% |
반응 단계
Lorazepam ethanol solvate (100 g) was suspended in a 1:1 mixture of dichloromethane and toluene (600 ml). The suspension was then heated to 25 ° C. for one hour and then cooled to 15° C. The suspension was filtered to recover the lorazepam crystals. The crystals were washed with toluene (20 ml) and dried at 50° C. under 65 mm Hg vacuum for two hours to give crystalline lorazepam (85 g, 90%)
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US06350870B2 |
|---|
| 출처 데이터셋 | uspto-grants-2002_02 |
|---|
| ORD ID | ord-9f8b1591cf314c2c8420f7db77e0162e |
|---|
| 출처 메모 | uspto-grants-2002_02 |
|---|
