1,2-Dibromoethane → 1-(2-Bromoethoxy)-4-iodobenzene

HRID 1700889노트

반응식

HRID 1700889 반응식
[I:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[CH:4][CH:3]=1.[Br:9][CH2:10][CH2:11]Br.C(=O)([O-])[O-].[K+].[K+]>>[Br:9][CH2:10][CH2:11][O:8][C:5]1[CH:6]=[CH:7][C:2]([I:1])=[CH:3][CH:4]=1

참가 물질

4

반응물 3

HCID 78391,2-DibromoethaneHCID 108944-IodophenolHCID 11430Potassium Carbonate

생성물 1

HCID 19058471-(2-Bromoethoxy)-4-iodobenzene수율 84%

실험 절차

A mixture of 4-iodophenol (15.0 g, 68.2 mmol) and 1,2-dibromoethane (50 ml, 580 mmol) and potassium carbonate (14.0 g, 0.1 mol) was stirred and refluxed for 22 h. After cooling to r.t., the mixture was filtered, washed with ethyl acetate and concentrated in vacuo. The residue was chromatographed on silica gel (Hexane/ethyl acetate 40:1 to 20:1) to afford the title compound (18.7 g, 84%) as a white solid.

후처리

  1. temperaturerefluxed for 22 h
  2. filtrationthe mixture was filtered
  3. washwashed with ethyl acetate
  4. concentrationconcentrated in vacuo
  5. customThe residue was chromatographed on silica gel (Hexane/ethyl acetate 40:1 to 20:1)

출처 및 근거

ORD 기록
ord-e13ce39eeaa34889902dcc3c10961964
출처 데이터셋
uspto-grants-2002_02
특허 번호
US06350892B1

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