1-Dodecanethiol → Ethanol, 2-(dodecylthio)-

HRID 1700929노트

반응식

HRID 1700929 반응식
Br[CH2:2][CH2:3][OH:4].[CH2:5]([SH:17])[CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16].C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O.C1(C)C=CC=CC=1>[CH2:5]([S:17][CH2:2][CH2:3][OH:4])[CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16]

참가 물질

6

반응물 3

HCID 81951-DodecanethiolHCID 108982-BromoethanolHCID 11430Potassium Carbonate

생성물 1

HCID 73835Ethanol, 2-(dodecylthio)-수율 77%

시약·촉매·용매 2

HCID 1140Toluene용매HCID 6228Dimethylformamide용매

반응 조건

온도
22 °C

실험 절차

A mixture of 2-bromoethanol (6.08 g, 48.7 mmol), dodecanethiol (9.86 g, 48.7 mmol) and potassium carbonate (11 g) in dry N,N-dimethylformamide (100 ml) was stirred at 22° C. for 10 h. The reaction mixture was then diluted with toluene (400 ml) washed with water and dried (magnesium sulfate). The solvent was evaporated under reduced pressure and the residue was filtered through a silica gel pad (toluene-ethyl acetate 95:5) and distilled under vacuum to give 9.18 g (77%) of 2-(dodecylthio)ethanol as a clear oil which solidified on standing: b.p. 100-105° C./0.01 torr (bulb to bulb distillation, air bath temperature); m.p. 31-32° C.

후처리

  1. washwashed with water
  2. dry with materialdried (magnesium sulfate)
  3. customThe solvent was evaporated under reduced pressure
  4. filtrationthe residue was filtered through a silica gel pad (toluene-ethyl acetate 95:5)
  5. distillationdistilled under vacuum

출처 및 근거

ORD 기록
ord-e9c06d325625480ea2a0933450fc5ea0
출처 데이터셋
uspto-grants-2002_02
특허 번호
US06350892B1

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