Leurosine sulfate → methyl (13S,15R,16R,18S)-13-[(1R,9R,10S,11R,12R,19R)-11-acetyloxy-12-ethyl-10-hydroxy-5-methoxy-10-methoxycarbonyl-8-methyl-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraen-4-yl]-18-ethyl-17-oxa-1,11-diazapentacyclo[13.4.1.04,12.05,10.016,18]icosa-4(12),5,7,9-tetraene-13-carboxylate

HRID 1701091

반응식

HRID 1701091 반응식
[CH3:1][CH2:2][C@@:3]12[O:22][C@@H:21]1[C@@H:19]1[CH2:20][N:5]([CH2:6][CH2:7][C:8]3[C:9]4[CH:10]=[CH:11][CH:12]=[CH:13][C:14]=4[NH:15][C:16]=3[C@@:17]([C:56]([O:58][CH3:59])=[O:57])([C:23]3[CH:24]=[C:25]4[C@:33]56[C@@H:37]7[C@:38]([CH2:53][CH3:54])([C@@H:42]([O:49][C:50]([CH3:52])=[O:51])[C@:43]([OH:48])([C:44]([O:46][CH3:47])=[O:45])[C@@H:32]5[N:31]([CH3:55])[C:26]4=[CH:27][C:28]=3[O:29][CH3:30])[CH:39]=[CH:40][CH2:41][N:36]7[CH2:35][CH2:34]6)[CH2:18]1)[CH2:4]2.OS(O)(=O)=O>O>[CH3:1][CH2:2][C@@:3]12[O:22][C@@H:21]1[C@H:19]1[CH2:20][N:5]([CH2:6][CH2:7][C:8]3[C:9]4[CH:10]=[CH:11][CH:12]=[CH:13][C:14]=4[NH:15][C:16]=3[C@@:17]([C:56]([O:58][CH3:59])=[O:57])([C:23]3[CH:24]=[C:25]4[C@:33]56[C@@H:37]7[C@:38]([CH2:53][CH3:54])([C@@H:42]([O:49][C:50]([CH3:52])=[O:51])[C@:43]([OH:48])([C:44]([O:46][CH3:47])=[O:45])[C@@H:32]5[N:31]([CH3:55])[C:26]4=[CH:27][C:28]=3[O:29][CH3:30])[CH:39]=[CH:40][CH2:41][N:36]7[CH2:35][CH2:34]6)[CH2:18]1)[CH2:4]2

참가 물질

3

반응물 1

HCID 259897Leurosine sulfate

생성물 1

HCID 442111methyl (13S,15R,16R,18S)-13-[(1R,9R,10S,11R,12R,19R)-11-acetyloxy-12-ethyl-10-hydroxy-5-methoxy-10-methoxycarbonyl-8-methyl-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraen-4-yl]-18-ethyl-17-oxa-1,11-diazapentacyclo[13.4.1.04,12.05,10.016,18]icosa-4(12),5,7,9-tetraene-13-carboxylate

시약·촉매·용매 1

HCID 962Water용매

실험 절차

About 0.25 g. of leurosine sulfate were converted to the free base by dissolving the salt in water and making the resulting solution alkaline. The free base was insoluble in the aqueous alkaline layer and was extracted with chloroform. Evaporation of the chloroform yielded leurosine free base as a residue.

후처리

  1. extractionwas extracted with chloroform
  2. customEvaporation of the chloroform

출처 및 근거

ORD 기록
ord-580e176d2e18422ea17dc317244860dc
출처 데이터셋
uspto-grants-1980_03
특허 번호
US04191688

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