N-methylhydroxylamine hydrochloride → 1-Hydroxy-1-methyl-3-(4,5,6,7-tetrahydrobenzo[b]thien-4-yl)urea

반응식

Cl.[CH3:2][NH:3][OH:4].[S:5]1[CH:9]=[CH:8][C:7]2[CH:10]([N:14]=[C:15]=[O:16])[CH2:11][CH2:12][CH2:13][C:6]1=2>>[OH:4][N:3]([CH3:2])[C:15]([NH:14][CH:10]1[C:7]2[CH:8]=[CH:9][S:5][C:6]=2[CH2:13][CH2:12][CH2:11]1)=[O:16]

참가 물질

반응물 2

HCID 77906N-methylhydroxylamine hydrochloride

HCID 205373014-Isocyanato-4,5,6,7-tetrahydro-1-benzothiophene

생성물 1

HCID 203489841-Hydroxy-1-methyl-3-(4,5,6,7-tetrahydrobenzo[b]thien-4-yl)urea

실험 절차

In the manner described in Example 6, N-methylhydroxylamine hydrochloride and 4,5,6,7-tetrahydrobenzo[b]thien-4-yl isocyanate are allowed to react to afford 1-hydroxy-1-methyl-3-(4,5,6,7-tetrahydrobenzo[b]thien-4-yl)urea, which is recrystallized from acetone-hexane-ether to give crystals, with melting point 98° C. to 102° C.

후처리

customto react

출처 및 근거

ORD 기록: ord-ae1699a3e1164dbe807af4bbce924237
출처 데이터셋: uspto-grants-1980_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04191830

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