Potassium cyanate → 2-Acetyl-4,5,6,7-tetrahydrobenzo[b]thien-4-ylurea

HRID 1701201노트

반응식

HRID 1701201 반응식
Cl.[C:2]([C:5]1[S:9][C:8]2[CH2:10][CH2:11][CH2:12][CH:13]([NH2:14])[C:7]=2[CH:6]=1)(=[O:4])[CH3:3].[O-:15][C:16]#[N:17].[K+]>O>[C:2]([C:5]1[S:9][C:8]2[CH2:10][CH2:11][CH2:12][CH:13]([NH:14][C:16]([NH2:17])=[O:15])[C:7]=2[CH:6]=1)(=[O:4])[CH3:3]

참가 물질

4

반응물 2

HCID 11378442Potassium cyanateHCID 203489702-Acetyl-4,5,6,7-tetrahydrobenzo[b]thiophen-4-amine hydrochloride

생성물 1

HCID 203489892-Acetyl-4,5,6,7-tetrahydrobenzo[b]thien-4-ylurea

시약·촉매·용매 1

HCID 962Water용매2회

반응 조건

온도
70 °C

실험 절차

A sample of 6.3 grams of 2-acetyl-4,5,6,7-tetrahydrobenzo[b]thiophen-4-amine hydrochloride is dissolved in 35 ml. of water and cooled to 15° C. A solution of 2.64 grams of potassium cyanate in 35 ml. of water is added, and after 0.5 hour the mixture is heated at 70° C. for about 40 minutes. The mixture is cooled, and the solid is collected and washed with water. On drying, 5.55 grams, melting point 218° C. to 220° C., of 2-acetyl-4,5,6,7-tetrahydrobenzo[b]thien-4-ylurea is obtained.

후처리

  1. temperatureThe mixture is cooled
  2. customthe solid is collected
  3. washwashed with water
  4. customOn drying

출처 및 근거

ORD 기록
ord-8b527c94101b402288fdccb8e4579dd7
출처 데이터셋
uspto-grants-1980_03
특허 번호
US04191830

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