Thionyl Chloride → HCID 20347860, 화합물

HRID 1701351노트

반응식

HRID 1701351 반응식
S(Cl)([Cl:3])=O.[C:5]([C:7]1[C:8]([CH3:16])=[C:9]([CH:13]=[CH:14][CH:15]=1)[C:10](O)=[O:11])#[N:6]>>[C:5]([C:7]1[C:8]([CH3:16])=[C:9]([CH:13]=[CH:14][CH:15]=1)[C:10]([Cl:3])=[O:11])#[N:6]

참가 물질

3

반응물 2

HCID 24386Thionyl ChlorideHCID 233592293-Cyano-2-methylbenzoic acid

생성물 1

HCID 20347860HCID 20347860, 화합물

실험 절차

75 cc of thionyl chloride and 30 g of 3-cyano-2-methyl-benzoic acid [prepared by process in C. R. Acad. Sci., Vol. 235(1952), p. 1660] were refluxed for 11/2 hours and after cooling, excess thionyl chloride was removed under reduced pressure. The last traces of thionyl chloride were removed by addition of benzene and distillation under reduced pressure. The residue was purified by rectification under reduced pressure to obtain 27.4 g of 3-cyano-2-methyl-benzoyl chloride in the form of colorless crystals melting at 62° C.

후처리

  1. temperatureafter cooling
  2. customexcess thionyl chloride was removed under reduced pressure
  3. customThe last traces of thionyl chloride were removed by addition of benzene and distillation under reduced pressure
  4. customThe residue was purified by rectification under reduced pressure

출처 및 근거

ORD 기록
ord-bea1d8e8a9cc424cbcc478e2bc6662ef
출처 데이터셋
uspto-grants-1980_03
특허 번호
US04192890

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