Triethylamine → 11beta-Dipropylaminoacetoxy-3alpha-hydroxy-5alpha-pregnan-20-one

HRID 1701430노트

반응식

HRID 1701430 반응식
[CH2:1]([N:4]([CH2:8][C:9]([O:11][C@H:12]1[CH2:31][C@@:30]2([CH3:32])[C@@H:23]([CH2:24][CH2:25][C@@H:26]2[C:27](=[O:29])[CH3:28])[C@H:22]2[C@H:13]1[C@:14]1([CH3:34])[C@@H:19]([CH2:20][CH2:21]2)[CH2:18][C:17](=[O:33])[CH2:16][CH2:15]1)=[O:10])[CH2:5][CH2:6][CH3:7])[CH2:2][CH3:3].C(N(CC)CC)C>C(=O)(O)[O-].[Na+].O.Cl.Cl.Cl[Ir](Cl)(Cl)Cl>[CH2:1]([N:4]([CH2:8][C:9]([O:11][C@H:12]1[CH2:31][C@@:30]2([CH3:32])[C@@H:23]([CH2:24][CH2:25][C@@H:26]2[C:27](=[O:29])[CH3:28])[C@H:22]2[C@H:13]1[C@:14]1([CH3:34])[C@@H:19]([CH2:20][CH2:21]2)[CH2:18][C@H:17]([OH:33])[CH2:16][CH2:15]1)=[O:10])[CH2:5][CH2:6][CH3:7])[CH2:2][CH3:3]

참가 물질

5

반응물 2

HCID 8471TriethylamineHCID 7058369811beta-Dipropylaminoacetoxy-5alpha-pregnane-3,20-dione

생성물 1

HCID 2281032311beta-Dipropylaminoacetoxy-3alpha-hydroxy-5alpha-pregnan-20-one

시약·촉매·용매 2

HCID 16211483Tetrachloroiridium--hydrogen chloride--water (1/2/1)촉매HCID 516892Sodium Bicarbonate용매

실험 절차

11β-Dipropylaminoacetoxy-5α-pregnane-3,20-dione (300 mg) was added to a solution of chloroiridic acid reagent (10 ml) containing triethylamine (1.1 ml). The mixture was boiled for about 20 minutes, cooled and diluted with sodium bicarbonate solution and the precipitated solid collected by filtration to afford title compound, m.p. 107°-115°, [α]D +91.3° (230 mg).

후처리

  1. temperaturecooled
  2. filtrationthe precipitated solid collected by filtration

출처 및 근거

ORD 기록
ord-b6694a3c81e8453abc5839ffbb513d5d
출처 데이터셋
uspto-grants-1980_03
특허 번호
US04192871

반응 노트

불러오는 중…