Carbon Dioxide → N-(2,6-Diethyl-phenyl)-N'-tert.-butyl-thiourea

HRID 1701561노트

반응식

HRID 1701561 반응식
[CH2:1]([C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([CH2:9][CH3:10])[C:4]=1[N:11]=[C:12]=[S:13])[CH3:2].C([C:16]1C=CC=[C:19](CC)[C:17]=1[NH2:18])C.[C:25](=O)([O-])[O-].[Ca+2].C(Cl)(Cl)=S.C(=O)=O>C(Cl)Cl.O>[CH2:1]([C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([CH2:9][CH3:10])[C:4]=1[NH:11][C:12]([NH:18][C:17]([CH3:19])([CH3:25])[CH3:16])=[S:13])[CH3:2]

참가 물질

8

반응물 5

HCID 280Carbon DioxideHCID 10040ThiophosgeneHCID 10112Calcium CarbonateHCID 113692,6-DiethylanilineHCID 1411932,6-Diethylphenyl isothiocyanate

생성물 1

HCID 20346927N-(2,6-Diethyl-phenyl)-N'-tert.-butyl-thiourea

시약·촉매·용매 2

HCID 962Water용매HCID 6344Dichloromethane용매2회

실험 절차

2,6-Diethyl-phenyl isothiocyanate can be prepared as follows: 100 g of 2,6-diethylaniline in 200 ml of methylene chloride are added dropwise at 0°-5°, whilst stirring, to a mixture of 500 ml of methylene chloride, 300 ml of water, 120 g of calcium carbonate and 92 g of thiophosgene. The mixture is then heated to the reflux temperature until the evolution of CO2 has ended. The cooled batch is filtered and the methylene chloride layer is separated off, dried with calcium chloride and fractionated.

후처리

  1. filtrationThe cooled batch is filtered
  2. customthe methylene chloride layer is separated off
  3. dry with materialdried with calcium chloride

출처 및 근거

ORD 기록
ord-f9f97215daf94e67ae5df4197d44dfa3
출처 데이터셋
uspto-grants-1980_03
특허 번호
US04194008

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