3-Nitro-N-(pyridin-4-yl)pyridin-2-amine → HCID 12445535, 화합물

HRID 1701702노트

반응식

HRID 1701702 반응식
[N:1]1[CH:6]=[CH:5][C:4]([NH:7][C:8]2[C:13]([N+:14]([O-])=O)=[CH:12][CH:11]=[CH:10][N:9]=2)=[CH:3][CH:2]=1.[H][H]>C(O)C>[N:1]1[CH:2]=[CH:3][C:4]([NH:7][C:8]2[C:13]([NH2:14])=[CH:12][CH:11]=[CH:10][N:9]=2)=[CH:5][CH:6]=1

참가 물질

4

반응물 2

HCID 124453923-Nitro-N-(pyridin-4-yl)pyridin-2-amineHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 12445535HCID 12445535, 화합물

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A solution of 16.5 g of 2-(4-pyridylamino)-3-nitro-pyridine in 400 ml of 95% ethanol containing 1.6 g of 10% palladized carbon was hydrogenated at 30°-40° C. at atmospheric pressure until 5.8 liters of hydrogen were absorbed and the mixture was filtered to remove the catalyst. The filtrate was evaporated to dryness and the residue was taken up in petroleum ether. The mixture was filtered to obtain 13.5 g (95% yield) of raw product melting at 202°-204° C. which was crystallized from 95% ethanol to obtain 2-(4-pyridylamino)-3-amino-pyridine in the form of a pale yellow, crystalline powder melting at 203°-205° C.

후처리

  1. customwere absorbed
  2. filtrationthe mixture was filtered
  3. customto remove the catalyst
  4. customThe filtrate was evaporated to dryness
  5. filtrationThe mixture was filtered
  6. customto obtain 13.5 g (95% yield) of raw product melting at 202°-204° C. which
  7. customwas crystallized from 95% ethanol

출처 및 근거

ORD 기록
ord-dc5289a80a244ddf826de2a0350af6b0
출처 데이터셋
uspto-grants-1980_03
특허 번호
US04195088

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