3-Nitro-N-(pyridin-2-yl)pyridin-2-amine → 2-(2-Pyridylamino)-3-amino-pyridine
반응식
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[NH:7][C:8]1[C:13]([N+:14]([O-])=O)=[CH:12][CH:11]=[CH:10][N:9]=1.[H][H]>C(O)C>[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[NH:7][C:8]1[C:13]([NH2:14])=[CH:12][CH:11]=[CH:10][N:9]=1참가 물질
4
실험 절차
A solution of 18.3 g of the product of Step A in 550 ml of 95% ethanol containing 1.6 g of 10% palladized carbon was hydrogenated at atmosphere pressure at room temperature until 6.3 liters of hydrogen were absorbed (about one hour) and the mixture was filtered to remove the catalyst. The filtrate was evaporated to dryness under reduced pressure and the 15.8 g of residue (98.6% yield) which was easily changed in air was used for the next step immediately.
후처리
- customwere absorbed (about one hour)
- filtrationthe mixture was filtered
- customto remove the catalyst
- customThe filtrate was evaporated to dryness under reduced pressure
출처 및 근거
- ORD 기록
- ord-c8212fcf136443a2a04210e5f649363b
- 출처 데이터셋
- uspto-grants-1980_03
- 특허 번호
- US04195088
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