Thiophenol → 2-Chloro-3-(phenylsulfanyl)pyrazine
반응식
[C:1]1([SH:7])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Cl:8][C:9]1[C:14](Cl)=[N:13][CH:12]=[CH:11][N:10]=1.C[O-].[Na+]>C(O)C>[Cl:8][C:9]1[C:14]([S:7][C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)=[N:13][CH:12]=[CH:11][N:10]=1참가 물질
5
반응 조건
- 온도
- 0 °C
실험 절차
22 g (0.2 mol) of thiophenol and 29.8 g (0.2 mol) of 2,3-dichloropyrazine are successively added dropwise to a solution of 10.8 g (0.2 mol) of sodium methylate in 200 ml of ethanol and the mixture is stirred for 1 hour. The reaction mixture is then cooled to 0° C. and the reaction product which has precipitated is filtered off and washed with ethanol and water. After drying, 2-chloro-3-phenylthiopyrazine, melting point 100°-111° C., is obtained.
후처리
- customthe reaction product which has precipitated
- filtrationis filtered off
- washwashed with ethanol and water
- customAfter drying
출처 및 근거
- ORD 기록
- ord-5c31e928649b4acaab557fce19c3add8
- 출처 데이터셋
- uspto-grants-1980_03
- 특허 번호
- US04195090
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